载脂蛋白与缺血性心血管病危险因素聚集的分析

A study on the relationship between serum apolipoprotein and risk factors of ischemic cardio-cerebrovascular disease clustering

目的研究人群中血载脂蛋白(ApoAI、ApoB、ApoE、ApoB/A1)水平与心血管重要危险因素聚集的关系。方法按随机抽样的原则,调查了青岛市35～59岁的中年人群2287人,男性1631名,女性656名,平均年龄(44.70±5.99)岁。应用免疫比浊法测定血清ApoAI、ApoB、ApoE。结果①ApoAI、ApoB、ApoE、ApoB/AI总体均数分别为(1.36±0.22)g/L、(0.99±0.26)g/L、(4.89±1.83)mg/dl、0.75±0.23,总体异常检出率分别为12.77%、29.03%、28.82%、6.56%。②经Pearson相关分析,危险因素评分与ApoAI存在显著负相关,与ApoB、ApoB/AI、ApoE存在显著正相关;经调整年龄、性别、体重指数后的偏相关分析中,危险因素评分与ApoAI存在显著负相关,与ApoB、ApoB/AI、ApoE显著正相关。③经单因素Logistic回归分析,心血管危险因素聚集依次与ApoB/AI、ApoB、ApoE水平密切相关。④经多因素Logistic回归分析,ApoB/AI、ApoB、ApoE水平仍与缺血性心血管重要危险因素聚集密切相关。结论ApoB/AI、ApoB、ApoE独立于年龄、性别因素而与心血管危险因素聚集密切相关。

Objective To study the relationship between serum apolipoprotein and important cardiovascular risk factors clustering. Methods According to sampling survey principle, 2287 subjects aged 35-59 in Qingdao city were recruited. Among them, 1631 were men, 656 were female, and their average age was 44.70±5.99 years old. The subjects＇ serum Apolipoprotein AI（APOAI）, Apolipoprotein B（APOB） and Apolipoprotein E （APOE） were measured by immunoturbidimetry assay, the ratio of Apolipoprotein B/AI（APOB/AI was calculated. Results （1）In the study, the mean of APO AI, APO B, APO E and APOB/AI was 1.（36±0.22）g/L、（0.99±0.26）g/L、（4.89±1.83）mg/dl、0.75±0.23 respectively. The abnormality ratio of APO AI, APO B, APO E and APOB/AI was 12.77%, 29.03%, 28.82%, 6.56% respectively.（2）he correlation coefficients between serum APO AI, APO B, APO E and APOB/AI portant cardiovascular risk factors clustering, by Pearson correlate analysis and by Partial correlate analysis after adjusting for age, sex and body mass index respectively. The results of non-conditonal univariate Logistic regression indicated that APOB/AI, APO B and APO E were associated with important cardiovascular risk factors clustering. The results of non-conditonal multivariate stepwise Logistic regression indicated that APOB/AI, APO B and APO E were associated respectively. Conclusion There were a closely relationship between serum APOB/AI, APO B,APO E and the clustering of important cardiovascular risk factors in Qingdao middle-aged cadre, indepandant of age and sex.