不能手术切除晚期胃癌病人介入化疗的疗效观察

Intraarterial chemotherapy for advanced unresectable gastric cancer

目的探讨动脉内介入化疗治疗不能手术切除的晚期胃癌病人的临床疗效和毒副反应.方法对不能手术切除的晚期胃癌60例行动脉内介入化疗者作为对照组.32例行常规静脉滴注化疗者作为对照组.从肿瘤大小变化方面和生存时间方面进行对比观察.结果动脉内介入化疗有效率58.3%,静脉化疗有效率28.1%,平均生存时间、动脉内介入治疗为306d,静脉化疗为72d.两组比较差异有显著性.毒副反应静脉滴注组发生率高,主要为白细胞下降、恶心、呕吐等.结论动脉内介入化疗方法治疗不能切除的晚期胃癌临床疗效优于静脉化疗方法.

AIM To evaluate the therapeutic efficacy and side effect of intraarterial chemotherapy in comparison with systematical one for advanced unresectable gastric cancer. METHODS Patients with advanced unresectable gastric cancer received 5-Fu, MMC and CDDP either intraarterially（n=60）or systematically（n=32）, once a month for 3-6 months. RESULTS The total response rate was 58.3% for intraarterial group and 28.1% for systematical group. The average survival time was306 and 72 days for the two groups, respectively. More severe side effect was recorded in patients receiving systematical chemotherapy. CONCLUSION Intraarterial chemotherapy is superior to systematical one in both therapeutic effect and tolerance.