2004年山东省部分暴露者狂犬病毒抗体检测结果分析

Analysis on Experiment Results of Antibody Against Rabies Virus of Partial Expos ed People in Shandong Province in 2004

[目的]评价人用狂犬病疫苗的免疫效果。[方法]对狂犬病疫苗初次全程(5针)免疫者用ELISA检测狂犬病毒抗体。[结果]共接种狂犬疫苗1 108例,免疫后抗体阳性1 067例,阳性率为96.3%。年龄越小抗体阳性率越高、女性的抗体阳性率高于男性、在山东省疾病预防控制中心预防门诊外接种疫苗者抗体阳性率较低,差异均有统计学意义(P<0.01),不同疫苗间的抗体阳性率的差异无统计学意义(P>0.05)。[结论]人用狂犬病疫苗有很好的免疫效果,但对免疫失败者应加强免疫,以防狂犬病的发生。

[Objective]To evaluate immune effectiveness of rabies vaccine. [Methods]The subjects were first time inoculated full course （five doses） of rabies vaccine. Their antibody against rabies virus was detected using EI.ISA after 15 days of last dose injected. [Results]Total antibody positive rate was 96.3% （1 067/1 108） in which 94.7% were male and 97.9% female. The sexual difference was significant（ P 〈0.01）. With the increasing of age, the positive rates decreased clearly（ P 〈0.01）. The antibody positive rates in different kinds of rabies vaccines were not significantlg different（ P 〉0. 05）. The positive rates among place vaccine injected were significant（ P 〈0.01 ）. [Conclusion]Immunization of rabies vaccine is trustworthiness, but it need to reinforce to the people who＇s antibody is negative to prevente rabies.