不稳定性心绞痛患者肺炎衣原体IgG检测的意义

The Significance of Measuring Chlamydia Pneumoniae Infection in the Unstable Angina Patients

目的探讨不稳定性心绞痛患者血清肺炎衣原体IgG滴度与血清炎症标志物之间的关系。方法采用微量免疫荧光法(MIF)和酶联免疫法(ELISA)方法对86例经冠状动脉造影证实的冠心病患者血中肺炎衣原体IgG抗体(CpIgG)和肿瘤坏死因子-α(TNF-α)、白细胞介素-6(1L-6)、C-反应蛋白(CRP)的检测,其中不稳定性心绞痛(UA)患者34例,慢性稳定性心绞痛(CSA)患者52例。结果UA组和CSA组的CpIgG阳性率分别为61.76%及55.77%,但差异无显著性;而UA组患者的血清TNF-αI、L-6和CRP均较CSA组显著增高,单因素回归分析未能发现UA组心绞痛患者的血清CpIgG滴度与TNF-αI、L-6和CRP的相关性。结论UA组患者血清中的炎症标志物较CSA组显著增高,但肺炎衣原体的感染不是导致斑块不稳定的主要因素。

Objective To investigate the relationship between serum ehlamydia pneumoniae IgG titer with inflammatory markers in the unstable angina patients. Methods Micro-immunofluorescence was used to measure chlamydia pneumoniae IgG antibody, enzyme-linked immunoabsorbent assay was used to measure tumor necrosis factor-α, intedeukin-6 and C-reactive protein in 86 patients with coronary artery disease documented by coronary angiograym, there were 34 eases with unstable angnm and 52 patients with chronic stable angina. Results Seropositive for ehlamydia pneumonia was 61. 76% in the unstable angina group and 55.77% in the chronic stable angina group,but there was no significant difference between tw-o groups. However, the serum TNF-α, IL-6 and CRP in the unstable angina group patients were significant higher than that in the chronic stable angina group patients. Univariate regression analysis didn＇ t find any relationship between ehlamydia pneumoniae IgG antibody titer with TNF-α, IL-6 and CRP in the unstable angina group. Conclusion Inflammatory markers are elevated in the unstable angina patients, however, chlamydia pneumoniae infection was not the major factor to unstable atheroselotie plaque.