肿瘤射频热疗比吸收率与温度场仿真及影响参数的研究

The Simulation of SAR and Temperature Distribution and Parameters Analysis for Tumor RF Thermotherapy

针对非侵入性射频热疗的SAR及瞬态温度分布进行了物理、数学建模和数值模拟计算。该模型能正确反映电磁波在生物组织内的衰减,在温度场模拟中考虑了血液灌流量随组织温度变化和肿瘤区低血液灌流的特点,使模拟结果更加符合临床实际。我们还对射频热疗电磁能量分布和温度分布的特点、特别是电磁波频率、血液灌流等因素对有效治疗深度的影响作了细致的分析和讨论。对指导射频热疗临床实践具有重要的指导意义。

In this paper are reported the model establishment and numerical simulation of specific absorption rate（SAR） and the unsteady temperature distribution for the non-invasive tumor RF thermotherapy. The model can correctly reflect the attenuation of electromagnetic wave in the biotissue, the variation of perfusion with temperature and lower perfusion of the tumor tissue are fully considered in the simulation. These measures made simulation results more close to the clinical results. Also presented in the paper are detailed analyses and discussions on the characteristics of SAR of electromagnetic energy and the temperature profiles, the effects of the frequency and the perfusion on the depth for effective treatment, The simulation results are of great significance for directing the clinical application of tumor RF thermotherapy.