急性心肌梗死患者溶栓前后血浆BNP、IL-6及CRP水平变化

The change of Serum BNP,IL-6 and CRP level before and after thrombolysis in the patients with acute myocardial infarction

目的:检测AMI患者溶栓前后血浆BNP、IL-6及CRP水平,探讨其变化特点及临床意义。方法:用ELISA法对66例AM I患者溶栓前后和53名健康正常人血BNP、IL-6及CRP水平进行检测。结果:AM I患者溶栓前血清BNP、IL-6及CRP水平显著高于对照组(P<0.01);溶栓前后血清BNP、IL-6及CRP水平差异显著(P<0.05)。结论:动态检测AM I患者溶栓前后血清BNP、IL-6及CRP水平变化,有利于观察溶栓疗效、指导治疗及预后判断。

Objective Brain natriuretie peptide （BNP） , Interleukin - 6 （ IL - 6 ） and C - reactive protein （CRP） before and after thrombolysis in acute myocardial infarction（AMI） were measured to explore their change characteristics and clinical sig- nificance, Methods Sixty - six patients diagnosed as AMI by coronary angiography received thrombolysis and 53 healthy subjects were as the control. Peripheral Venous blood was taken before and after thrombolysis, BNP, IL -6 and CRP were measured by ELISA. Results The average levels of plasma BNP, IL - 6 and CRP in the AMI patients were higher than that in the control group（ P 〈 0.01 ） ,their levels in AMI patients before thrombolysis were higher than those after thrombolysis （ P 〈 0.05 ）. Conclusion BNP, IL - 6 and CRP measurement may help us evaluate the prognosis of AMI and the efficacy of thrombolysis.