胸腺肽对扁平疣患者血清白介素-10和γ干扰素水平的影响及疗效分析

Effect of thymic peptide on serum levels of IL-10 and IFN-γ and its efficacy in patients with varruca planea

目的研究胸腺肽对扁平疣患者血清白介素-10(IL-10)、γ干扰素(IFN-γ)水平的影响及疗效。方法采用酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)双抗体夹心技术检测扁平疣患者治疗组、对照组治疗前后及正常人血清IL-10、IFN-γ水平。结果治疗前两组扁平疣患者IL-10水平都明显高于正常人,IFN-γ水平明显低于正常人(P<0.01),两组患者间IL-10、IFN-γ水平相近(P>0.05)。治疗后胸腺肽组IL-10水平显著降低,并明显低于对照组,IFN-γ水平显著升高,也明显高于对照组(P<0.01),而对照组治疗前后水平差异无统计学意义(P>0.05),且治疗组的疗效(总有效率80.76%)明显高于对照组的46.15%(P<0.05)。结论扁平疣患者存在TH1/TH2型细胞因子失衡,胸腺肽可通过纠正此种细胞因子失衡而改善患者免疫功能,提高治疗效果。

Objective To observe the effect of thymic peptide on the serum levels of IL-10 and IFN-γ in patients with varruca planea and the effect of treatment. Methods Double-antibody sandwich ELISA was used to detect the serum levels of interleukin-10 （IL-10） and interferon gamma （IFN-γ） in normal persons and varruca planea patients with thymic peptide and control before and after treatment. Results Before treatment, the serum levels of IL-10 were significantly higher in patients, while the levels of IFN- γ were significantly lower than that in normal people （P〈0. 01 ）. The levels of IL-10 in the thymic peptide group were decreased, while the levels of IFN-γ were increased after treatment （P〈0. 01）. There were no significant changes in control group （P〉0.05）. The levels of IL 10 in the thymic peptide group were lower than those of control group , while the levels of IFN γ were higher than those of control group after treatment （p〈0.01）. Effective rates in treatment group （80.76%） were higher than those of con- trol group （ 46. 15^, P〈0.05）. Conclusion Cellular immunity is impaired in varruca planea patients. Thymic peptide can enhance cellular immunity of the patients. Therefore varruca planea patients receive some better effects with thymic peptide.