新生大鼠下丘脑神经元发育过程中膜特性变化

Postnatal Development of Membrane Properties of Rat Hypothalamic Neurons

大鼠出生后下丘脑神经元温度敏感性逐步升高,采用电流钳技术发现,膜被动特性在出生后18d内变化显著,同时峰电位升高,动作电位间期延长,前电位及后电位均有明显的变化,大多数神经元表现为单次放电.这些结果表明发育过程中离子通道的密度和活动特性发生了改变,同时温度敏感性与突触特性存在着一定的关系.

Thermosensitivity of hypothalamic neurons increases gradually after the birth of the rat. Patch-clamp technique was used to investigate the membrane properties of these neurons and the results suggested that the neurons exhibited significant changes of their passive properties, increasing of the spike, prolonged AP duration and variations of both pre- and post- potential. Most of these neurons remained single firing. It was then concluded that the density and activity of ion channels changed during the process of development and the thermosensitivity of these neurons may be modulated by synaptic activity.