复方虫草多糖脂质体口服液对慢性乙型肝炎细胞免疫的影响

Effect of Compound Cordyceps Sinensis Liposome Oral Liquid on the Immunity of Chronic Hepatitis B Cell

目的:探讨复方虫草多糖脂质体口服液对慢性乙型肝炎细胞免疫的影响。方法:113例慢性乙型肝炎患者随机分为两组,治疗组57例,对照组56例,两组均给予门冬钾镁、肌苷、VitC等基础治疗,治疗组加用复方虫草多糖脂质体口服液,观察治疗前后外周血单个核细胞(PBMC)T细胞数量及各群比例关系及IL-2、IFN-γ含量。结果:治疗后治疗组PBMC CD4+T淋巴细胞数量及CD4+／CD8+比值较对照组明显增高(P<0．01,P<0．05),培养上清液IL-2、IFN-γ含量明显增高(P<0．01,P< 0．05)。结论:复方虫草多糖脂质体口服液能促进慢性乙肝患者PBMC产生CD4+T淋巴细胞、IL-2、IFN-γ,能明显增强慢性乙型肝炎患者的细胞免疫功能。

Objective： To explore the effect of cordyceps sinensis liposome oral liquid on the cell immunity of chronic hepatitis B patients. Method： 113 patients with chronic hepatitis B were randomly divided into two groups. There were 57 cases in the therapeutic group and 56 cases in the controlled group, They were all given potassium and magnesium aspartates, inosine, vitamin C and etc, as the basic therapy. The therapy was given cordyceps sinensis liposome oral liquid. Before and after therapy, the PBMC, the T-lymphocyte count and the proportion between the groups were observed. The levels of IL-2, IFN-γ were determined by radioimmunoassay. Resuit： After the therapy, the PBMC, CD4^＋ T lymphocyte of therapeutic group were significantly higher than those in controlled group（P 〈 0.01 ）. The value of CD4^＋/CD8^＋ and the content of IL-2, IFN-3, were higher（ P 〈 0.05 ） . Conclusion： The compound cordyceps sinensis liposome oral liquid can improve the PBMCs of patients with chronic hepatitis B to produce CD4^＋ T lymphocyte, IL-2, IFN-γ）, and improve the cell immunological function.