果糖和纳洛酮联合治疗急性酒精中毒的研究

Study of Fructose and Nalooxone Therapy on Acute Alcoholism

目的:观察果糖和纳洛酮联合治疗急性酒精中毒的疗效;方法:对5％果糖注射液和纳洛酮注射液进行配伍稳定性考察,确定可配伍使用;采用前瞻性单盲随机对照研究,将110例患者随机分为两组:56例急性酒精中毒患者(试验组)用果糖和纳洛酮联合治疗,54例急性酒精中毒患者(对照组)单用纳洛酮治疗。结果:试验组和对照组临床观察指标有统计学差异 (P<0．01);结论:5％果糖注射液和纳洛酮注射液对治疗急性酒精中毒有协同作用,值得在临床抢救中推广使用。

Objective ： To observe the effect of fructose and nalooxone in the treating acute alcoholism. Method ： Firstly, observing the compatibility and stability of 5% fructose injection and nalooxone injection in order to define the usage compatibility. Then 110 patients were divided to two groups randomly. 56 patients in the therapeutic group were treated with fructose and nalooxone while 54 patients in the controlled group were treated with nalooxone only. Result： There was significant difference of the clinical indicators be- tween the therapeutic group and controlled group（ P 〈 0.01 ）. Conclusion： There is coordination function of 5% fructose injection and nalooxone injection in the acute alcoholism therapy. And the combined therapy should be applied in the clinical emergency rescue more.