伴有血小板减少的系统性红斑狼疮34例分析

Analysis of 34 cases of systemic lupus erythematosus with decreased platelet count

目的了解伴有血小板减少的系统性红斑狼疮临床及实验室检查特征。方法对34例伴有血小板减少的系统性红斑狼疮与随机抽取的40例血小板正常系统性红斑狼疮患者的临床特点进行对照研究,分析其首发症状、临床表现及实验室检查改变。结果血小板减少组肾脏损害的发生率高于血小板正常患者,但蝶形红斑的发生率低于后者,均有统计学意义(P<0.05),实验室指标,CH50、白细胞下降程度和尿蛋白出现率明显高于血小板正常组,而血小板比容、血小板分布宽度出现异常高于血小板正常组。结论伴有血小板减少的系统性红斑狼疮患者临床及实验室检查与血小板正常患者比某些程度存在差异。

Objective To explore the clinical and laboratory examination features of systemic lupus erythematosus （SLE） with decreased platelet count. Methods Thirty-four SLE patients with decreased platelet count were analyzed for their initial symptoms, clinical manifestations, involvement of the organs and laboratory findings in comparison with 40 randomly selected SLE patients with normal platelet count. Results The SLE patients with decreased platelet count were more likely to develop kidney involvement than those with normal platelet, but the incidence of butterfly erythema was significantly lower in the former patients （P〈0.05）. Some indices of laboratory examinations, such as CH50, white blood cell reduction, rate of urine protein, thrombocytocrit and platelet distribution width were significantly higher in SLE patients with decreased platelet count than those with normal platelet count. Conclusion The clinical manifestations and laboratory findings in SLE patients with decreased platelet count may differ from those of SLE patients with normal platelet.