通窍活血汤对犬急性心肌缺血、心脏血流动力学及心肌耗氧量的影响

EffectS of Tongqiao Huoxue Decoction on Acute Myocardial Ischemia,Cardiac Hemodynamics and Myocardial Oxygen Consumption in Dogs

观察了通窍活血汤对犬急性心肌缺血、心脏血流动力学及心肌耗氧量的影响。结果表明：通窍活血汤可明显减轻心肌缺血程度（∑－ＳＴ），缩小经Ｎ－ＢＴ染色所显示的梗塞区；增加冠脉血流量，扩张冠脉血管；增加动脉血压、左室内压、ｄｐ／ｄｔ＿（ｍａｘ）、心输出量及左室作功，提高心肌收缩力；降低心肌耗氧量，改善氧的供需平衡。提示该方剂对心肌缺血有明显的保护作用。

The effects of Tongqiao Huoxue Decoction(THD)on acute myocar-dial ischernia,cardiac hemodynamics and myocardial oxygen consumption in dogs were studied.The results den1onstrated that THD could significantly improve the following parameters in the experiments:the damage degree of myocardial ischemia(∑-ST),myocardial ischemia area by stained with N-BT,coronarv blood flow,dila-tion of coronary artery,arterial blood pressure(ABP),left ventricle diastolic pres-sure(LVDP)and dp/dt_(max),cardiac output and left ventricle work,myocardial con-traction force, myocardial oxygen consumption,and the equilibrium of oxygen sup-ply and demand,indicating that THD exerted significantly protective action on my-ocardial iscbemia.