^(99m)Tc-MDP骨显像定量分析旋股动脉机械性阻断致股骨头缺血性坏死的实验研究

Experiment research of avascular necrosis of the femoral head after ligating different blood vessels supplying femoral head by bone imaging of ^(99m)Tc-MDP and quantitative analysis

目的观测阻断实验兔股骨头旋股内、外侧动脉后股骨头血流改变,为临床选择不同方法治疗股骨头缺血性坏死(ANFH)提供依据。方法根据结扎动脉的不同将实验兔分成A、B、C 3组,于术后不同时间用单光子发射计算机体层摄影术(SPECT)检测实验侧股骨头(E头)、实验侧股骨干(E干)、对照侧股骨头(C头)及对照侧股骨干(C干)的放射性计数,并计算比值。结果C头/C干比值为2.72。A组和B组术后2 h和3 d E头/C头和E头/E干比值明显下降,两组间无显著性差异(P>0.05);C组E头/C头和E头/E干比值轻度下降,与A、B组之间均有显著性差异(P<0.05)。结论99mTc-MDP骨显像及定量分析可以反映股骨头血运变化,对ANFH诊断、治疗及预后有指导意义。

Objective To observe the viability of blood flow after ligating different blood vessels supplying femoral head and to provide basis for choosing different treatment of avascular necrosis of femoral head （ANFH）. Methods The rabbits were divided into A, B and C group, and their medial or lateral femoral circumflex arteries were ligated. The radioactive count of experimental femoral head （Ehead）, experimental femoral shaft （Eshaft）, control femoral head（Chead）and control femoral shaft （Cshaft）of rabbits were measured by single photon emission computed tomugraphy in the second hour, the third day, the fourth week and the eighth week after operation. Results Chead/Chead is 2.72. Ehead/Chead and Ehead/Eshaft, of A and B groups decreased distinctively, no significant difference was found between these two groups（ P 〉 0.05）. Ehead/Chead and Ehead/Eshaft, of C group decreased indistinctivly, significant difference were found between C group and A or B groups （ P 〈 0.05）. Conclusion The viability of blood flow could be observed, bone imaging of ^99mTc-MDP and quantitative analysis could provide conductive significance for diagnosis, treatment and prognosis of ANFH.