肿瘤基因治疗中两种新的靶向分子

Two Molecules as New Targets in the Gene Therapy of Cancer

肿瘤基因治疗通过适当的载体在肿瘤细胞中表达抗癌基因以治疗癌症。目前肿瘤细胞中发现很多重要的致癌相关分子,它们有些与肿瘤细胞无限繁殖密切相关,有些能够抑制细胞的凋亡,有些能够促进肿瘤细胞血管新生或者逃避免疫监视。这些分子无疑是今后肿瘤基因治疗中的理想靶向分子。本文选取了目前肿瘤基因治疗研究中较新并具有一定代表性的2种致癌相关分子：缺氧诱导因子1(HIF-1)、信号转导与转录活化因子3／5(STAT3／5),对其特点及其在癌症治疗中的应用作一综述。

The gene therapy of cancer is a cancer-treatment technique by expressing anticancer genes in tumor cells by rationally designed vectors. Nowadays, more and more crucial molecules in tumor cells have been identified that are related to the unlimited proliferation of cancer cells. Some can inhibit the apoptosis, some can promote angiogenesis, and some can help tumor cell evade immune surveillance. These molecules are ideal targets in future cancer gene therapy. This article reviews the features and the application of two important molecules in tumor cells： hypoxia-inducible factor 1 （ HIF-1 ）, signal transducer and activator of transcription 3/5 （STAT3/5）