1,3,4-唑啉类化合物的合成与结构表征唑恶

Synthesis and structural characterization of 1,3,4-Oxadiazolines

苯甲酰肼在乙醇中,回流条件下,与芳醛和苯乙酮反应得到相应的酰腙(2a～2h),然后再进一步与乙酸酐环合,以良好的收率合成出了1,3,4-卟恶唑啉类衍生物(3a～3h)。通过元素分析,IR,1HNMR和MS对其结构进行表征,并对其裂解途径进行了探讨。

Benzoyl hydrazine was synthesized by reaction ot etnyt oenzate with Condensation of （1） with benzaldehyde, 4-chlorobenzaldehyde, 2-chlorobenzaldehyde, 2,4-dichlorobenzaldehyde, 3- bromobenzaldehyde, 4-methoxybenzaldehyde, furaldehyde and acetylbenzene produced corresponding hydrazones （2a-2h）. Cyclization of intermediates with acetic anhydide gave the title compounds （3a-3h） in good yield. Structures products were confirmed by elementary analyses, IR, ^1H NMR, and MS spectroscopy, and fragmentation mechanism of MS spectra was discussed as well.