光化性角化病药物盐酸δ-氨基酮戊酸的制备

Synthesis of a new drug of treating actinic keratosis-δ-aminolevulinic acid

盐酸δ-氨基酮戊酸是一种新型的治疗光化性角化病药物,该药是一种光敏性药物,应用于光动力学治疗。本文提供了一个三步反应合成δ-氨基酮酸的简便方法。用该方法可以在温和条件下合成出该药,最终产品的纯度大于98%。

δ-aminolevulinic acid is an new drug of treating actinic keratosis. It is a kind of photosensitive drug, and can be used in photodynamic therapy. A facile 3-step synthesis of δ-aminolevulinic acid has been performed. The drug was synthesis in high yield under moderate conditions. The purity of the final product was more than 98%（HPLC）.