2型糖尿病合并冠心病患者血清残粒脂蛋白胆固醇水平测定及其临床意义

Determination of serum remnant lipoprotein cholesterol of patients with coronary heart disease in type 2 diabetes mellitus and its clinical significance

目的探讨血清残粒脂蛋白胆固醇(RLP-C)在2型糖尿病合并冠心病患者中水平变化及其临床意义。方法用免疫分离法测定45例2型糖尿病合并冠心病、42例2型糖尿病无冠心病患者及44例正常对照组血清RLP-C水平,同时测定了3组人群的TC、TG、LDL-C、LP(a)和HDL-C水平。结果2型糖尿病合并冠心病患者的血清RLP-C水平〔(0.45±0.25)mmol/L〕明显高于2型糖尿病无冠心病〔(0.26±0.19)mmol/L〕和正常对照组〔(0.19±0.11)mmol/L,P<0.01〕。2型糖尿病患者血清RLP-C水平与TG成正相关。结论2型糖尿合并冠心病患者血清RLP-C水平显著升高,RLP代谢异常可能是2型糖尿病合并冠心病的重要危险因素之一。

Objective To investigate serum remnant lipoprotein cholesterol （RLP） of patients in type 2 diabetes mellitus with coronary heart disease and its clinical significance. Methods Serum RLP-C level was assayed using immunoseparation method in 45 patients of type 2 diabetes mellitus with coronary heart disease, 42 patients without coronary heart disease and 44 controls. Simultaneously,serum TG, TC, HDL-C, LP（a） and LDL-C were also determined. Results Serum RLP-C [（0.45±0.25）mmol/L] in type 2 diabetes mellitus with coronary heart disease increase significantly in comparison with serum RLP-C [（0.26±0.19） mmol/ L] in type 2 diabetes mellitus without coronary heart disease and serum RLP-C [（0.192±0.11 ） mmol/L] in controls. Linear correlation analysis showed that serum RLP-C concentration was correlated positively with TG in patient with type 2 diabetes mellitus. Conclusion Serum RLP-C in type 2 diabetes mellitus with coronary heart disease increase significantly . The abnormality of RLP metabolization is a critical factor for coronary heart disease in type 2 diabetes mellitus.