摘要
本文采用高效液相色谱法测定血药浓度,对10名健康自愿者,口服雷尼替丁胶囊的药代动力学进行了研究。药时曲线均符合血管外给药开放性一室模型,所得参数与国内外报道的数据在统计学上无明显差异(P>0.05)
The pharmacokinetics of ranitidine was studied with the method of high performance li-quid chromatography in 10 healthy volunteers. The subjects were given a single dose of ranitidine 150mg (one capsule) orally. The serum concentration-time curves showed that one-compartment open model could be used in all subjects. The equation of mean serum conccentration was and with following pharmacokinetic parameters: (hr), and There were no statistically significant differences between the, kinetic parameters of reported articles and ours
出处
《重庆医科大学学报》
CAS
CSCD
1989年第1期22-25,共4页
Journal of Chongqing Medical University
关键词
雷尼替丁
药化动力学
ranitidine
pharmacokineties
high performance liquid chromatography
