健脾补肾活血泄浊法治疗慢性尿酸性肾病38例临床研究

Clinical Observation on 38 cases of Chronic Uric Acid Nephropathy Treated by Invigorating the Spleen and Kidney and Promoting Blood Flow and Diminishing Turbid

[目的]观察活血泄浊汤治疗慢性尿酸性肾病(CUAN)的临床疗效。[方法]将68例患者随机分为2组,对照组30例在基础治疗的同时加服别嘌呤醇,治疗组38例在与对照组相同治疗的基础上加活血泄浊汤治疗,均治疗3个月观察统计临床疗效。[结果]总有效率治疗组为92.11%,对照组为63.33%,2组比较,差异有显著性意义(P<0.05);治疗后治疗组在24h尿白蛋白、BUA、BUN、Scr、血脂4项、血液流变学等等指标较治疗前均有不同程度改善(P<0.05,P<0.01)。[结论]活血泄浊汤配合别嘌呤醇治疗CUAN,能降低患者的血尿酸,改善肾功能,改善血脂代谢及血液高凝状态,有效阻止CUAN的病情发展。

[Objective] To observe the clinical curative effect of HuoxueXiezhuo（activating blood circulation and dispelling turbid） decoction in treating chronic uric acid nephropathy（CUAN）. [Methods] Sixty-eight patients were randomly divided into the treatment group and control group. The control group was administered with allopurinol on the background of basic treatment. The treatment group was administered with HuoxueXiezhuo decoction imposed on the same treatment as in control group. Clinical curative effect was observed after three months. [Result] The total effective rate of treatment group was 92.11% and that of control group was 63.33%. There was obviously difference（P〈0.05） in the total effective rate between treatment and control group. The urinary albumin in twenty-four hours, BUA, BUN, Scr, blood fat and haemorheology,etc were improved at different extent （P〈0.05, P〈0.01）. [Conclusion] HuoxueXioezhuo decoction may reduce the blood uric acid and improve the kidney function, blood fat metabolism and blood hyper-coagulation state. The treatment group may effectively inhibit the disease progression.