乙肝患者PT、APTT、FIB检测的临床意义

The clinical significance of measurement for PT,APTT and FIB in the patients with hepatitis B.

目的探讨乙型肝炎患者血液凝血状态的改变和凝血指标检测的临床意义。方法采用法国STA-Compact全自动血凝仪检测136例乙型肝炎患者和15例健康者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(FIB)水平,并对两组结果进行比较分析。结果肝硬化、重症肝炎组的PT、APTT、FIB与正常组比较,差异有显著性(P<0.05,P<0.01)。慢性肝炎组的FIB水平较正常组有显著性差异(P<0.05),PT、APTT则无显著性差异(P>0.05)。结论乙肝患者的凝血状态随肝脏损害程度的加深而有明显改变,各测定值的异常与肝脏损害程度相一致。

Objective To analyze the variation of the coagulation state and its clinical significance in the patients with hepatitis B. Methods 136 venous blood samples from the patients with hepatitis B were measured for plasm prothrombin time （PF）, activated partial thromboplastic time （AFIT）, fibrinogen （FIB） by STA -Compact automated coagulation analyzer from the normal subjects were measured as control. Results The PF, APTT , FIB values of the groups of hepatocirrhosis and grievous hepatitis B showed clinically significant differences compared with the healthy control＇s. （ P 〈0.05, P 〈0.01 ）. However, the differences in PF, APTT values of the group of chronic hepatitis B were not significant （ P 〉0. 05 ）. FIB values of it showed significant differences compared with the healthy controlg （ P 〈0.05 ）. Conclusion The coagulation state in the patients with hepatitis B varied evidently during the deepen of the liver impairment. The abnormal values showed identical significance with the lever impairment.