新型MRI对比剂钆贝葡胺在肝脏占位病变中的初步应用

Initial Clinical Application of Gadobenate Dimeglumine (Gd-BOPTA) in Liver Space-Occupying Lesions

目的评价新型磁对比剂钆贝葡胺(Gd-BOPTA)在肝脏占位病变中的诊断价值。方法对10例B超及CT检查提示有肝占位性病变病例进行常规MRI检查和用Gd-BOPTA增强后立即扫描以及30min、60min、90min、120min扫描,有2例延迟至6h和24h扫描。扫描序列SET1WI、FSET2WI平扫、3D-SPGRT1及SET1WI进行动态和延迟扫描。平扫观察病变与正常肝脏组织在各个序列图像上的信号及对比。使用Gd-BOPTA增强后观察,肝实质的强化特征及比较两种扫描序列对肝脏病灶的显示情况,动态及延迟双期扫描的病灶强化特点及形态学的改变。结果使用Gd-BOPTA增强检查后,发现8例肝癌,2例血管瘤,肝实质长时间保持持续强化稳定状态,最高峰为60min,最长强化时间达24h,GRE较SE在肝脏病变的显示中更有优势,通过双期扫描,病灶显示的更清晰,诊断更明确。结论作为非特异性钆剂的新一代顺磁性对比剂,Gd-BOPTA对肝脏的强化持久稳定,通过动态和延迟的双期扫描能提高肝脏占位病变检出的敏感性和特异性,是一种具有良好发展前景的磁共振对比剂。

Objective：To evaluate the diagnostic value of gadobenate dimeglumine （Gd-BOPTA） enhancement MRI in liver space-occupying lesions. Methods： 10 cases of hepatic space-occupying lesions suggested by B-mode ultrasonography and CT underwent 1.5T MR imaging immediately after,and 30、60 and 90 minutes after Gd-BOPTA injection. T1- and T2- weighted spin-echo and T1-weighted gradient-echo images were acquired. The signal intensity and morphologic features of liver parenchyma and lesions on images in the various phases after enhancement were observed and analyzed. Results： In eight cancer patients and two hemangioma patients, the liver parenchyma depicted prolonged, steady, enchanced images, The GRE techniques could be used in preference over SE techniques. Hepatic hemangiomas and hepatomas could be detected effectually from their typical enhancement features during the dynamic and equilibrium phase. Conclusion： Gd-BOPTA can enhance the liver parenchymal signal for a long time and increase the detection rate of heptic lesions during the dynamic and delayed phase in MR imaging.