胆囊病变组织中雌激素与孕激素受体表达和成石原因相关研究

Correlation between the expression of estrogen receptor and progesterone receptor in gallbladder pathological tissue and the pathogenesis of formation of stones

目的探讨胆囊病变组织雌激素受体(ER)与孕激素受体(PR)的表达及其在发病中的作用。方法采用免疫组化法进行ER、PR的检测。结果胆囊癌、胆囊炎伴胆石症患者的阳性表达率明显高于胆囊炎伴胆固醇沉着症、胆囊息肉及单纯性胆囊炎患者(P<0.05),ER及PR在胆囊癌及胆囊炎伴胆石症中的阳性表达率分别为100%、70%及100%、50%,其阳性表达率在胆囊炎伴胆石症、胆囊癌中呈现由少到多的关系。结论雌激素通过诱导该受体表达增加了形成胆囊结石并进一步发展为胆囊癌的易感性。

Objective To investigate the expression of estrogen receptor （ER） and progesterone receptor （PR） in gallbladder carcinoma and cholecystitis, to study the effect of estrogen and progesterone on ovallhladder carcinoma and the complication of cholecystitis. Methods ER and PR were detected by immunohistochemistry. Results The expressions of ER and PR were lower in cholecystitis, polyp of ~nhladder and simple cholecystitis than those in patients with gallbladder carcinoma and gall stone disease （ P 〈 0.05）. The expression rates of ER and PR in gallbladder carcinoma and gallstone disease were 100% ,70% ,which were 100% ,50% in cholecystitis complicated with cholethiasis, which showed that the positive rate in cholecystitis gallstone was lower than that in gallbladder carcinoma. Conclusion The estrogen may induce its receptor to increase the susceptibility of the pathogenesis of formation of stones,which may develop into gallbladder carcinoma.