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药物特异质肝毒性的发生机制及预测筛选方法 被引量:4

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摘要 药物特异质肝毒性(ILT)是近年来多种药物撤出市场或标注“黑框”标志的主要原因,也是导致药物开发后期失败的重要原因之一。本文综述了近年来ILT的发生机制,药物开发早期ILT的预测筛选,以及寻找生物标志物方面所取得的研究进展,并提出了未来研究的主要方向。
出处 《国外医学(药学分册)》 2005年第5期338-341,共4页 Foreign Medical Sciences(Section of Pharmarcy)
基金 国家高技术研究发展计划(2002AA2Z34D)
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