弓形体感染与儿童智力发育障碍的初步研究

A PRELIMINARY STUDY ON RELATIONSHIP BETWEEN TOXOPLASMA INFECTION AND INTELLIGENCE DEFICIENCY IN CHILDEN

用乳胶凝集试验(Latex agglutination)和酶联免疫吸附试验(Enzyme-Iinked immunosorbent assay)检测79对弱智儿童及母亲、107对智力正常儿童及母亲血清弓形体抗体。结果表明:两法有良好一致性。两项试验双阳性率依次为6.33,8.86、0和0.93％。弱智组双阳性率显著为高(P<0.05)。19例合并先天性畸形的弱智儿童双阳性率为15.7％,显著高于智力正常儿童或无先天性畸形的弱智儿童(0％,3.33％,P<0.01)。因此,弓形体感染可能是造成儿童智力发育障碍的病因之一,并与儿童先天性畸形有一定关系。建议国内对孕妇常规进行血清弓形体抗体检查。

This paper reports the results of latex agglutination (LA) and enzyme-linked immunoso-rbent assay (ELISA) for detecting the specifie anti-Toxoplasma antibody positive rates among 79 cases of intelligence deficiency children and their mothers, and 107 cases of intelligence-normal children and their mothers. The results indicated that between the results of LA and ELISA a good coincidence was presented.The anti-Toxoplasma antibody both positive rates of LA and ELISA wen: 6.38, 8.36, O and 0.93% respectively. The both positive raves of intelligence deficiency children and mothers group were signifiantly higher than that of intelligence-normal children and mothers group. In 19 intelligence deficiency children with congenital malformation, the both positive rate was 15.79%, and was significantly higher than that of 107 intelligence-normal children (0%), and 60 intelligence deficiency without congenital malformation children (3.33%) respectively. Therefore,Toxoplasma infection may be one of the potential pathogenic causes of intelligence deficiency and congenital malformation in children. We suggest that routine examinations for anti-Toxoplasma antibody in pregnant women be carried out