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丙戊酸抗肿瘤作用研究进展 被引量：3

Progress of antitumor effects of vlproic acid
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摘要 丙戊酸(VPA)是目前临床上广泛应用的广谱抗癫痫药,近年来发现它同时还是组蛋白去乙酰化酶抑制剂(HDACI)。大量实验研究表明,丙戊酸可以通过诱导细胞周期停滞、凋亡和分化以抑制肿瘤细胞生长增殖,同时还具有抑制肿瘤血管生成和转移作用。丙戊酸的长半衰期和较好的生物利用性以及较低的有效药物浓度,使其作为一种新型抗癌药物有着更好的开发利用前景。
作者 杜华文 耿洁 荣风年
机构地区 山东大学临床医学院山东省千佛山医院妇产科
出处 《国外医学（肿瘤学分册）》 2005年第10期766-768,共3页 Foreign Medical Sciences (Cancer Section)
关键词 丙戊酸 组蛋白类 药物疗法 基因 抑制 肿瘤
分类号 R730.5 [医药卫生—肿瘤]
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参考文献20

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同被引文献34

  • 1燕敏,陈尔真,曹伟新,费旭峰,陈雪华.丁酸诱导结肠癌细胞凋亡机制的实验研究[J].肠外与肠内营养,2005,12(5):268-271. 被引量：1
  • 2王生余,张旭辉,于晓妉.新型抗肿瘤药物组蛋白去乙酰化酶抑制剂[J].国际肿瘤学杂志,2006,33(6):404-406. 被引量：12
  • 3时昌文,赵霞,曹莉莉,孙京杰,刘爱武.丙戊酸钠诱导胃癌细胞凋亡及其机制[J].中华胃肠外科杂志,2007,10(5):468-471. 被引量：4
  • 4Sakajiri S, Kumagai T, Kawamata N, et al. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines [ J ]. Exp Hematol,2005,33 : 53- 61
  • 5Hsi LC,Xi X,Lotan R,et al. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-1ipoxygenase-1 in colorectal cancer cells[ J]. Cancer Res ,2004,64:8778-8781
  • 6Gottlicher M. Valproic acid:an old newly discovered as inhibitor of histone deacetylases [ J ]. Ann Hematol, 2004, 83 :$91-92
  • 7Johnstone RW. Histone-deacetylase inhibitors:novel drugs for the treatment of cancer [ J ]. Nat Rev Drug Discov, 2002,1 : 287-299
  • 8Children's Oncology Group,Fouladi M,Furman WL,et al. Phase Ⅰ study of depsipeptide in pediatric patients with refractory solid tumors:a Children's Oncology Group report [ J ]. J Clin Oncol,2006,24 : 3678-3685
  • 9Zhang Y ,Jung M, Dritschilo A, et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors [ J ]. Radiat Res, 2004,161:667-674
  • 10Shabbeer S, Kortenhorst MS, Kachhap S, et al. Multiple molecular pathways explain the anti-proliferative effect of valproic acid on prostate cancer cells in vitro and in vivo [ J]. Prostate,2007,67:1099-1110

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国外医学（肿瘤学分册）
2005年 第10期

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