骨基质明胶的临床应用

BONE MATRIX GELATIN ALLO-IMPLANTS IN CLINICAL USE

本文报告15例同种骨基质明胶(BMG)的临床应用结果,其中7例为良性骨肿瘤,都为BMG的诱导成骨所治愈;1例脊柱融合术也由BMG的骨诱导所融合;7例长骨于骨折不连接,仅3例发生骨性愈合,4例失败,其中2例再植BMG,再次失败。全组病人均无早期感染或免疫排斥反应。

Seven cases of benign bone tumors, a case of spinal fusion and. seven rases of un-united fractures of shafts of long bones, were treated with a.llogenir bone matrix gelatin (BMG) implants and were followed up for more than one year. All tumor cases were cured by osteo-induction from BMG, while only three of the seven fractures united. Two of the failures were reimplanted with BMG and failed again. Not a single case developed post-operative infection nor immunologic reaction. The BMG used was obtained from the same preparation, so that deterioration of its biological activity by endogenous protease was not likely. BMG small BMG cubes were used in tumor cases and slabs in fractures. The small cubes . were mixed with pieces of gel-foam and parked into the post-operative bony cavities while the slabs were arranged layer by layer at the fracture sites. This might be one of the reasons why the tumor rases had higher rate of cure Another reason was that non-unions needed prolonged, continuous and firm internal and external fixation post-operatively while the tumor cases needed not The amount of BMP calculated from BMG was not enough for early and solid osteogenesis. In the authors'opinion, with the use of new biomaterial, it should be followed by new method of application, but the principles of surgery should not be changed