人肺癌组织活化CPT-11能力的实验研究

The experiment study about the ability of CPT-11 activating in lung cancer tissues

目的:通过对肺癌组织局部羧酸酯酶的检测,间接了解局部活化CPT-11的能力。方法:应用免疫组化方法检测70例肺癌组织中羧酸酯酶表达。结果:肺鳞癌、肺腺癌、小细胞肺癌的阳性率分别为48.6%、52.2%及75.0%。小细胞肺癌羧酸酯酶阳性率高于非小细胞肺癌,但无统计学意义。Ⅰ期肺癌标本阳性率48.0%,Ⅱ、Ⅲ期肺癌标本阳性率分别为57.7%和52.6%。结论:肺癌组织可在局部利用羧酸酯酶活化CPT-11,小细胞肺癌的局部活化CPT-11能力可能强于非小细胞肺癌;肺癌病程发展过程中羧酸酯酶的表达没有发生明显变化。

Objective To study the ability of activating CPT-11 in lung cancer tissues through the examination of the human hepatocyte carboxylesterase in the human lung cancer tissues. Method Using the immunohistochemical methods 70 cases of human lung cancer tissues the expression of human hepatocyte carboxylesterase of was examined. Results the positive rate of the squamous cell type, the adenocarcinoma type and the small cell type was 48.6%, 52.2%, 75.0% respectively. The positive rate of small cell lung cancers was higher than that of the non-small cell lung cancers but had no statistic difference. The positive rate of stage Ⅰ lung cancer was 52.0% whereas the positive rate of the Ⅱand Ⅲ stage were 57.7% and 52.6% respectively. Conclusion The local lung cancer tissues can use the human hepatocyte carboxylesterase to activate CPT-11, especially in the small cell lung cancer tissues.There was no significant difference in the expression of human hepatocyte carboxylesterase during the development of lung cancer.