急性冠状动脉综合征sCD40L水平的临床意义

The clinical significance of serum soluble CD40L level in coronary heart disease

目的:探讨急性冠状动脉综合征(ACS)患者血清可溶性CD40L(sCD40L)水平变化的临床意义。方法:应用酶联免疫法(Enzyme-linkedImmunosorbentAssay,EIA)对入选的60例ACS患者(不稳定型心绞痛,UA)48例、急性心肌梗死(AMI)12例的外周血sCD40L水平进行检测,及60名正常对照者血清sCD40L的浓度进行检测。结果:ACS组血清sCD40L水平明显较对照组高(P<0.01);AMI血清sCD40L明显高于UA组高(P<0.05);随访期ACSsCD40L增高组心血管事件发生率明显高于正常组。结论:sCD40L的升高在ACS发生和发展中起重要作用,是反应斑块不稳定性的指标之一。

Objective To investigate the clinical significance of the serum level of soluble CD40 ligand （sCD40L） in acute coronary syndrome. Method Enzyme-hnked immunosorbent assay （EIA） was used to measure sCD40L in 60 patients with acute coronary syndrome （48 with unstable angina pectoris and 12 with acute myocardial infarction） and 60 matched healthy controls. Results sCD40L level was significantly higher in patients with acute coronary syndrome （ACS） than that of controls （P〈0.01）, and significautly higher in patients with acute myocardial infarction than that of those with unstable angina pectoris （P〈0.05）. Incidence of high risk of cardiovascular event during follow - up period was higher in patients with high sCD40L level than that of those with normal sCD40L level. Conclusion The levels of sCD40L increase in acute coronary syndrome , which may be related to the pathogenesis of ACS, can be used as a potential marker of plaque instability.