用于深部组织导热率测量的热敏电阻探针的制备及初步实验研究

Thermoelectricity resistance probe for measuring thermal conductivity of deep tissues: design and initial experimental study

目的:介绍一种微创的测量组织导热率的热敏电阻探针的制作方法。方法:采用美国GE公司生产的珠状热敏电阻1kΩ,Φ0.5mm,将该电阻用医用树脂胶粘连于20GPTC针尖端。控制电路由北京工业大学生物医学工程中心研制。从制作好的10根探针中随机抽取3根,对已知导热率的液体材料进行测量,数据采集器记录测量数据并存入微型计算机进行处理。结果:单针测量数据的重复性比较好。3根探针同种液体的测量值之间的差异无显著统计学意义。结论:该热敏电阻探针可以方便地用于超声引导下插入深部组织,进行导热率的测量,也可以用于活体动物及临床患者深部组织导热率的实时测量。

Objective To develop a minimal-invasive thermistor probe for measurement of tissue thermal conductivity. Materials and Methods Thermoelectricity resistances （GE, USA） with a diameter of 0.5cm and a value of lkl） were fixed to the tip of 20G FTC needle with resinous adhesive. The control unit of the measuring system was produced by Biomedical Engineering Center of Beijing Polytechnic University.3 probes were selected from a total of 10. Measurements of four liquid materials with known thermal conductivities were performed. Data were collected and fed into the computer for analysis. Results The measurements by a single probe have good repeatability. No statistical significance was found for the measurements by three probes. Conclusion The thermoelectricity resistance probe can be inserted into deep tissue conveniently when guided by US and because of its minimal invasiveness, it also can be applied to in vivo measurements of thermal conductivities.