国产奥沙利铂与氟尿嘧啶、亚叶酸钙联合治疗晚期大肠癌

Clinical Study of Oxaliplatin plus Fluorouracil and Calcium Folinate in Treatment for Advanced Colorectal Cancer

[目的]研究奥沙利铂(L-OHP)与氟尿嘧啶(5-Fu)及亚叶酸钙(CF)联合治疗晚期大肠癌的疗效和毒副反应。[方法]38例晚期大肠癌,国产奥沙利铂130mg/m2,静脉滴注2h,d1;亚叶酸钙200mg/d,静脉滴注2h,d1￣5;氟尿嘧啶500mg/m2,静脉滴注4h,d1～5(CF滴完后);21天为1个周期,治疗2个周期后评定疗效。[结果]37例可评定疗效患者中,CR1例,PR11例,SD22例,PD3例,有效率(CR+PR)32.4%。毒副反应以Ⅰ～Ⅱ度消化道症状、骨髓抑制、感觉神经毒性为主,有一定的肝损害。[结论]奥沙利铂与氟尿嘧啶、亚叶酸钙联合治疗大肠癌疗效确切,毒副反应能耐受。

[Purpose] To evaluate the clinical efficacy and toxicity of oxaliplatin plus 5-Fu/CF combination in advanced colorectal cancer. [Methods] Thirsty-eight patients with advanced colorectal cancer were treated with oxaliplatin plus 5-Fu/CF. Oxaliplatin 130 mg/m^2 iv, 2 hours, d1, calcium folinate 200mg/d iv, 2 hours, d1-5, followed by fluorouracil 500 mg/m^2 iv, 4 hours, d1-5s, repeated every 21 days. [Results] In thirty-seven evaluable cases, there were CR, 1 case; PR, 11 cases; SD, 22 cases; PD, 3 cases. The overall response rate （CR＋ PR） was 32.4%. The main adverse effects were nausea and vomiting, neurosensory toxicity and neutropenia. [Conclusion] The regimen of oxaliplatin combined with 5-Fu/CF is effective, and tolerable in advanced colorectal cancer.