注射用阿莫西林钠致急性肾衰竭15例分析

Clinical analysis of 15 cases with acute renal failure caused by amoxicillin through intravenous injection

[目的]分析静脉注射阿莫西林钠导致急性肾衰竭的原因,以减少药物不良反应的发生。[方法]总结15例静脉注射阿莫西林钠致急性肾衰竭的临床表现、辅助检查结果、治疗及预后。[结果]静脉注射阿莫西林钠致急性肾衰竭起病急,100%出现剧烈腰痛或下腹痛伴肉眼血尿,66%伴有少尿,肾功检查尿素氮(16.65±11.19)mmol/L肌酐(472.5±325.67)μmol/L,出现症状即停药15 d内可以进入多尿期,3个月后随诊肾功能恢复正常。[结论]严格掌握注射用阿莫西林钠的剂量和浓度。

[ Objective] To analysis the reason of acute renal failure caused by amoxicillin through intravenous injection, and to reduce the side effect of drugs. [ Methods] To summary the clinical manifestations, laboratory tests, treatment and pi＇ognosis of 15 cases with acute renal failure caused by amoxicillin through intravenous injection. [ Results] Acute onset, sever lumber or lower abdominal pain with gross hematuria occurred in almost all of cases, oliguria could be seen in 66% of cases, BUN （16.65 ± 11.19）mmol/L Scr（472.5 ± 325.67）μmol/L, amoxiciUin was forbidden immediately when ARF was diagnosed, and ARF had a good prognosis after active treatment. [ Conclusion] Strictly master the dose and concentration of amoxiciUin.