EB病毒感染者肿瘤坏死因子及白介素2水平研究

Clinical Study on Serum TNF-α and IL-2 Level in the Cases Infected of EB Virus

目的:研究鼻咽癌高发区EB病毒感染者肿瘤坏死因子(TNF-α)及白介素2(IL-2)水平。方法:免疫酶法检测血清EBVCA-IgA确定EB病毒感染者44例为观察组,以健康人18例作为对照组,ELISA法测定血清TNF-α及IL-2水平;比较其血清TNF-α及IL-2水平。结果:EB病毒感染者及健康对照者TNF-α分别为(37.5±18.7)pg/mL及(23.2±9.6)pg/mL,P<0.01;而IL-2分别为(14.4±7.1)pg/mL及(18.7±6.4)pg/mL,P<0.05。结论:EB病毒感染者肿瘤坏死因子水平增高而白介素2水平低下。

Objective ：To test the serum TNF-αand IL-2 level in the cases infected of EB Virus. Methods ：The EB Virus titer was tested as immunoenzyme method and the serum TNF-α and IL-2 were tested by ELISA methods. The 44 EB Virus infected cases were the observation group, and the 18 health people were the control group. Results ： The health people serum TNF-α level is （23.2 ± 9.6）pg/mL, and The EBV- infected cases serum TNF-α level is （37.5 ± 18.7）pg/mL, P 〈 0.01. The health people serum IL-2 level is （ 18.7 ＋- 6.4）pg/mL, and The EBV-infected cases serum IL-2 level is （ 14.4±7.1 ）pg/ mL, P 〈 0.05. Conclusion ： The cases infected of EB Virus has higher serum TNF-α level and lower serum IL-2 level.