老年男性冠心病患者体内性激素水平的研究

Study on the changes of sexual hormone in the old patients with coronary heart disease

目的探讨老年男性冠状动脉粥样硬化性心脏病(CHD)患者其体内性激素水平的变化与血脂之间的关系。方法所有研究对象均检测雌二醇(E2)、睾酮(T)、血脂、射血分数(EF)水平,比较各组间上述指标的水平差异并进行相关分析。结果CHD心力衰竭组和非心力衰竭组间E2、T、E2/T水平差异无显著性(P>0.05),CHD组E2及T水平明显低于非CHD组(P<0.05),而E2/T在CHD组明显高于非CHD组(P<0.05);E2、T、E2/T水平与冠脉狭窄程度、冠脉病变支数、冠脉病变评分之间无相关性,而EF值及血脂水平则与之相关;CHD患者E2水平与HDL-C水平呈显著负相关,与TC、LDC-C、TG、LP(a)水平呈显著正相关,T与血脂间无显著相关性。结论老年男性CHD患者体内性激素水平明显下降,且以雄性激素下降为主;体内性激素水平与CHD的严重程度无关;体内雌激素水平与血脂代谢有明显相关,而雄激素变化与血脂代谢无明显相关。

Objective To investigate the changes of sex hormone in the old patients with coronary heart disease （CHD）. Methods The level of estradiol（ E2 ）, testosteron （ T）, blood lipids and ejection fraction （EF） were detected and analyzed. Results There was no obvious statistic difference of E2 , T, E2/T between CHD patients with heart failure and those without, but the level of E2 and T in CHD group was significantly lower than that in non-CHD group and E2/T in CHD group was higher than that in non-CHD group. There was no statistical correlation between the level of E2 , T, E2/T and the number of pathologic coronary, stenosis degree, coronary lesion score, but there was remarkable correlation between EF, blood lipids and the number of pathologic coronary, stenosis degree, coronary lesion score. Conclusions The level of sex hormone decreases obviously in the old patients with CHD, and especially the male hormones ; There is no obvious correlation between the level of hormone and the degree of CHD; There is obvious correlation between estrogens and blood lipids but no correlation between androgens and blood lipids.