毛细胞白血病经白细胞干扰素治疗后的超微结构观察

ULTRASTRUCTURAL STUDY ON A CASE OF HAIR CELL LEUKAEMIA TREATED WITH HUMAN LEUKOCyTE INTERFERON

本文应用透射电镜观察1例毛细胞白血病,经用小剂量(1.5×10~4单位/日×27天)人白细胞干扰素治疗后的骨髓细胞超微结构改变,发现该药对毛细胞的损伤主要表现为核周间隙扩大,核膜崩解,糙面内质网扩大、泡状化及出现髓样结构等。对粒细胞系统及红细胞系统也有类似轻微改变。

A female patient with hair cell leukaemia was treated with human leukocyte interferon at a daily dose of 1.5 × 104 for 27 days. The bone marrow cells were studied with electron microsepy. The follow up investigation of the bone marrow hair cells revealed that there were widening of the perinuclear space, disintegration of nuclear membrane, vaeuolization as well as expansion of the rough endoplasmic retieulum