特发性肺纤维化27例临床分析

Idiopathic pulmonary fibrosis: a clinical analysis of 27 cases

目的通过探讨特发性肺纤维化(IPF)的临床特点,提高对IPF的认识。方法对27例符合美国胸科协会提出的IPF诊断标准的IPF患者进行回顾性分析。结果男女之比为19∶8,年龄45～76岁,伴有咳嗽、进行性呼吸困难和Velcro罗音,X线表现为磨玻璃样、网状、结节状及蜂窝状阴影。肺功能检查示18例限制性通气功能障碍,9例混合性通气功能障碍。血气分析示低氧血症。糖皮质激素可使患者病情得到近期缓解。结论对长期咳嗽伴有进行性呼吸困难的患者,及时行胸部X线、肺功能、血气分析及经支气管肺活检,能对本病做出正确的诊断。

Objective To have a gain in knowledge of idiopathic pulmonary fibrosis （IPF） by investigating its clinical feature.Methods Retrospective analysis was conducted on 27 cases of IPF according to the diagnostic criteria formulated by the America Thoracic Society and the European Respiratory Society.Results The patients （male 19, female 8）, aged 45-76 years, had cough accompanied by ＇progressive dyspnea and Velcro tale. X-ray examination showed glassy, reticular, nodular and alveolate lesions;18 of them had restrictive ventilation dysfunction and 9 of them had combined ventilation dysfunction.Arterial blood gas analysis indicated hypoxemia.Glucocorticoid could improve patient＇s condition in the near future.Conclusion To perform examinations such as chest X-ray, pulmonary function, arterial blood gas analysis and TBLB on patients with chronic cough and dyspnea in time is necessary for the diagnosis of IPF.