脑胶质瘤VEGF表达与动态增强MRI灌注成像的相关性研究

Correlation between dynamic contrast-enhanced MR imaging and the expression of VEGF in cerebral gliomas

目的:探讨脑胶质瘤血管内皮生长因子(VEGF)表达与动态增强MRI灌注成像之间的相关性。材料与方法:对37例证实为脑胶质瘤的患者术前行动态增强MRI灌注成像,获得反映局部血流灌注的3个参数,rrCBV、rrCBF、TTP*,对术后的病理切片采用免疫组化法测定组织内VEGF的表达。分析VEGF与胶质瘤组织学级别的关系,并对血流动力学参数与VEGF表达间进行相关性检验。结果:VEGF在不同级别胶质瘤组中的表达具有显著性差异,VEGF与rrCBV、rrCBF具有明显的正相关,r分别为0.699和0.558。结论:VEGF作为促进胶质瘤血管生成最重要的调节因子,其表达程度的高低与分级密切相关,动态增强MRI灌注成像可以作为预测VEGF表达的一种新方法,从而为抗血管治疗提供依据。

Objective： To study the correlations between the expressions of VEGF in cerebral gliomas with its pathologic grade and dynamic contrast-enhanced MR imaging. Methods： Dynamic contrast-enhanced MR imaging was performed in 37 glioma patients preoperatively. The perfusion data were processed to obtain three parameters reflecting the microcirculation： Max rrCBV, rrCBF and TrP＊. The expressions of VEGF were measured using immuno-bistocbemical technique. The correla- tions between the expression of VEGF, pathologic grade of tumor and dynamic MRI parameters were studied. Results： Differences of the VEGF expressions among three grade groups of tumor were statistically significant. The expression of VEGF was significantly positive correlated with the Max rrCBV, rrCBF（r-=0.699, P=0.001; r=0.558, P=0.011） respectively. Negative correlation were found between VEGF and TTP＊, no statistical significance can be observed. Conclusion： As the most important regulation factor, VEGF has close relation with pathologic grade. Dynamic contrast-enhanced MR imaging can be used to assess the expression of VEGF, the technique has a good prospect in clinical antivascular therapy.