阿司匹林抵抗

Aspirin Resistance

阿司匹林抵抗是指阿司匹林不能:(1)保护服用者不发生血栓性并发症;(2)延长出血时间;(3)抑制血栓素的生物合成或(4)在体外试验中对血小板功能发挥预期影响。阿司匹林抵抗的可能机制包括:(1)5%～40%的缺血性血管病并非动脉粥样硬化所致;(2)依从性差或剂量不足。阿司匹林抵抗尚无特异性治疗方法。对于不能耐受阿司匹林或出现阿司匹林抵抗的患者,应选择ADP受体拮抗剂氯吡格雷或其他抗血小板药治疗。

Aspirin resistance has been used to describe the inability of aspirin to： （1） protect individuals from thrombotic complications; （2） cause a prolongation of the bleeding time; （3） inhibit thromboxane biosynthesis; or （4） produce an anticipated effect on one or more in vitro tests of platelet function. The possible mechanisms of aspirin resistance include： （1） 5- 40% ischemic angiopathy is not caused by arteriosclerosis; （2） poor compliance or insufficient dosage for aspirin. There is no specific therapy for aspirin resistance. For patients who cannot tolerate aspirin or in whom it has not been effective, adenosine diphosphate （ADP） receptor antagonists, such as clopidogrel or other antiplatelet drugs should be used instead.