孕激素与围绝经期情绪障碍相关性的探讨

The Exploration of Relationship between Progestin and Peri-menopausal Emotional Disorder

目的:探索孕激素在女性围绝经期情绪障碍中的作用。方法:研究对象以抑郁为主伴或不伴焦虑的围绝经期女性57例,及参加体检的、经Zung氏焦虑抑郁自评量表筛选后无抑郁焦虑症状群的围绝经期健康女性 37例,两组年龄范围均介于40-60岁。主要评定工具为HAMD、HAMA、SAS、SDS等量表,并于入院后次晨空腹抽血检测孕激素。结果:HAMD、HAMA评分在女性围绝经期情绪障碍组和健康对照组之间存在着统计学差异(P< 0．01);情绪障碍组的孕激素水平虽然略高于健康对照组,但两者之间差异无统计学意义(P>0．05);情绪障碍组的孕激素与HAMD评分之间没有相关性,而与HAMA评分之间有低度相关性(P<0．05)。结论:孕激素在女性围绝经期情绪障碍的发生、发展中可能发挥着一定的作用。

Objective： To observe the effects of progestin on emotional disorder during peri-menopause in a clinical study. Method： 57 women patients with emotional disorder in Psychiatric Department of the Third Affiliated Hospital of Sun-Yat-Sen University were allocated into the case group, and 37 healthy women without emotional disorder by SDS and SAS screening tests were put into the control group, who were from the Maternal and Child Health Hospital of Haizhu District in Guangzhou City. They were all 40-60 years old. The leading Rating Scales were HAMA, HAMD, SAS, and SDS, and two milliliters of periphery venous blood were obtained for testing progestin level at eight clock in the morning. Result： ①The score of HAMA, HAMD presented some significant difference between the case and control groups. ②There was some statistical difference in progestin between the two groups. ③There was no relationship between progestin and HAMD in the case group, and there was a positive correlation between progestin and HAMA in the case group. Conclusion： Progestin could play a latent role in occurrence and progress of peri-menopausal emotional disorder.