急性缺血性卒中与短暂性脑缺血发作患者脂蛋白(a)和高密度脂蛋白水平初探

Study on the Levels of Lipoprotein(α) and High Density Lipoprotein between the Patients with Acute Ischemic Stroke and Transient Ischemic Attacks

目的探讨急性缺血性脑卒中与短暂性脑缺血发作(TIA)患者血浆脂蛋白a()、高密度脂蛋白胆固醇(H DLC-)、低密度脂蛋白胆固醇(LDLC-)水平。方法急性缺血性脑卒中组90例、TIA组52例及健康对照组54例,测定3组血浆脂蛋白a()、H DLC-、LDLC-水平。结果急性缺血性脑卒中组、TIA组、对照组脂蛋白a()分别为(157.88±58.87)m gL/、(186.32±76.19)m gL/、(224.15±89.12)m gL/,两组与对照组比较,差别有统计学意义P(<0.01);H DLC-分别为(1.15±0.24)m m olL/、(1.25±0.27)m m olL/、(1.38±0.26)m m olL/,两组与对照组比较,差别有统计学意义P(<0.01P,<0.05);LDLC-分别为(3.22±0.90)m m olL/、(2.89±0.59)m m olL/、(2.82±0.76)m m olL/,两组与对照组比较,差别无统计学意义P(>0.05);脂蛋白(a)水平与H DLC-、LDLC-无相关性。结论高脂蛋白(a)、低高密度脂蛋白胆固醇水平与急性缺血性卒中和短暂性缺血发作可能相关。

Objective In order to study the levels of lipoprotein（α） [Lp（α）], HDL-C and LDL-C in patients with ATS and TIA, Methads 90 patients with ATS （group1）, 50 patients with TIA （group 2） and 54 healthy persons as normal control （group 3） were selected and the levels of serum Lp（α）, HDL-C and LDL-C of these three groups were tested, Results The levels of Lp（α） in these three groups were respectively 157.88±58.87. 186.32±76.19 and 224.15±89.12 mg/L, and the values of Lp（α） in groupl and group2 were markedly different from that in group3 （P〈0.01）, The results of HDL-C were 1.15±0.24, 1.25±0.27 and 1.38±0.26 mmol/L, respectively. The values of HDL-C in groupl and group2 were significantly different from group3 （P〈0.01 and P〈0.05）, The levels of LDL-C were respectively 3.22±0.90, 2.89±0.59 and 2.82±0.76 mmol/L, and no statistic difference between these groups （P〉0.05）, The level of Lp（α） was not correlated with the contents of HDL-C and LDL-C, Conclusion It was suggested that the risk of TIA and AIS might be correlated with the high value of Lipoprotein（α） and the low value of HDL-C.