利培酮治疗Tourette综合征对照研究

Controlled study of risperidone in treatment of Tourette syndrome

目的:进一步验证利培酮治疗Tourette综合征的疗效和不良反应。方法:60例Tourette综合征患者分为两组,每组30例,分别给予利培酮和氟哌啶醇治疗。疗程6周。治疗前和治疗6周分别进行耶鲁综合抽动严重性量表(YGTSS)和副反应量表(TESS)评定疗效和不良反应。结果:两组治疗后YGTSS总分和各维度评分均显著低于治疗前,利培酮组显著高于氟哌啶醇组,利培酮组显效率为67.9%明显低于氟哌啶醇组96.7%;利培酮组不良反应明显小于氟哌啶醇组。结论:利培酮和氟哌啶醇均能有效治疗Tourette综合征,但利培酮疗效不及氟哌啶醇,利培酮不良反应少而轻。

Objective： To further testify the efficacy and side effects of risperidone in the treatment of Tourette syndrome. Method： Sixty patients with Tourette syndrome were randomly divided into risperidone group and haloperidol group to treat for six weeks. All the patients were evaluated with the Yale global tic severity scale （YGTSS） and treatment emergent symptom scale （TESS）. Results：After treatment, the total scores and the dimensional scores of YGTSS decreased significantly in both groups, but these scores were significantly higher in risperidone group than in haloperidol group. The effective rate in risperidone group（67.9% ） was significantly lower than that in haloperidol group（96.7%）. The side effects in resperidone group were significantly less than those in haloperidol group. Conclusion： Although both drugs are effective to Tourette syndrome, the effectiveness of risperidone is poorer than that of haloperidol and the side effects of risperidone is slighter than that of haloperidol.