奥氮平治疗酒精所致精神障碍对照研究

Comparative study of olanzapine in treatment of mental disorder due to alcohol

目的:探讨奥氮平对酒精所致精神障碍的临床疗效。方法:66例患者随机分入两组,分别服用奥氮平或氟哌啶醇6周,用阳性与阴性症状量表(PANSS)和副反应量表(TESS)评定疗效和不良反应。结果:奥氮平组有效率69.7%,显著较氟哌啶醇组42.4%为高。结论:奥氮平对酒精所致精神障碍的临床疗效优于氟哌啶醇,且不良反应较少。

Objective：To investigate the clinic ettects ot olanzaplne in me treatment of mental （nsorder oue to alcohol. Method：66 patients were treated with olanzapine or haloperidal for 6 weeks. Positive and negative symptom scale（PANSS） and treatment emergent symptom scale （TESS） were used to assess the clinic effects and side effects. Results： The therapeutic effect rate of olanzapine was 69.7% ,This was significantly higher than that of haloperidal 42.4 %. Conclusion：Olanzapine has better clinic efficacy than haloperidal in the treatment of mental disorders due to alcohol and less side effects.