摘要
[目的]探讨苦参碱注射液对溃疡性结肠炎(UC)患者外周血T细胞免疫的影响。[方法]采用免疫组化(SAP)法检测30例UC患者用苦参碱注射液治疗1月前、后和10例健康志愿者外周血T细胞亚群。[结果]30例UC患者中治愈7例,好转12例,无变化11例;UC患者CD8+Ts细胞明显减少;用苦参碱治疗后UC患者外周血CD3+、CD8+Ts细胞较治疗前明显增高,有效组CD8+Ts细胞显著高于无效组(P<0.05)。[结论]UC患者抑制性T细胞减低,免疫亢进;用苦参碱注射液治疗有较好疗效,外周血T细胞,尤其CD8+Ts细胞水平明显增高。
[Objective] To investigate the effect of matrine injection on the cellular immunity in peripheral blood in 30 patients with ulcerative colitis （UC）. [Methods] T cell subpopulation （TCS） in the peripheral blood of patients and healthy volunteers was respectively examined by SAP method. [Results] There were 7 complete responder （CR）, 12 partial responders （PR） and 11 non- responder（NR） at the end of matrine injection treatment. The percentage of CD3^＋TCL , CD8^＋ Ts in peripheral blood was increased remarkably after treatment and CD8^＋ Ts cells were also amplified significantly in CR or PR than in NR group. [Conclusion]Matrine injection can improve T cell , especially CD8^＋Ts in peripheral blood in patients with UC.
出处
《中国中西医结合消化杂志》
CAS
2005年第5期313-315,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
结肠炎
溃疡性
苦参碱注射液
T细胞亚群
细胞免疫
ulcerative colitis（UC）
matrine injection
T cell subpopulation （TCS）
cellular immunity
