重组人促红细胞生成素对冠状动脉搭桥手术患者的脑保护作用

Effects of cerebral protection by recombination human erythropoietin during coronary artery bypass graft surgery

目的研究重组人促红细胞生成素(rhEPO)对冠状动脉搭桥手术患者的脑保护作用。方法将冠状动脉搭桥患者随机分组,实验组术前应用rhEPO,通过患者术后临床表现、精神量表评分以及血清脑特异性蛋白(S100B蛋白)浓度测定,研究rhEPO的脑保护作用。结果实验组与对照组相比,术后认知障碍发生率低,精神量表评分高,S100B蛋白浓度无明显升高。结论冠状动脉搭桥患者术前预防性应用rhEPO可以减轻某些因素导致的脑损伤。

[Objective] To investigate the effects of recombination human erythropoietin on cerebral protection during coronary artery bypass graft surgery. [Methods] Patients underwent coronary artery bypass graft surgery were divided into test group and control group randomly, the former were administrated rhEPO before surgery. Through the rate of cognitive dysfunction, neuropsychologic scale assessment and concentration of serum S100B protein, ef- fects of cerebral protection by rhEPO were evaluated. [Results] The patients in test group had lower rate of cogni- tive dysfunction, higher score of neuropsychologic scale assessment and stable concentration of serum S100B protein. [Conclusion] Administration of rhEPO before CABG can attenuate cerebral injure caused by certain factors.