高压氧综合治疗持续性植物状态患者的探讨

ASSESSMENT OF THE EFFICACY OF COMBINED HYPERBARIC OXYGEN THERAPY FOR PATIENTS WITH PERSISTENT VEGETATIVE STATE

目的：评价高压氧综合治疗持续性植物状态患者的疗效并探讨其作用机理。方法：自１９９４年３月至１９９５年３月一年间，在常规治疗的基础上，应用高压氧治疗持续性植物状态患者８例（病因为严重颅脑损伤４例、脑出血２例、脑梗塞１例、脑膜瘤术后１例，其中昏迷时间最长为２８１天，其次为１４１天）；治疗压力为０．２ＭＰａ，吸纯氧４０分钟×２次，中间吸空气１０分钟，每天治疗１次，１０次为１个疗程。治疗次数最短者２０次，最长者８６次。结果：本组８例患者经上述治疗后全部清醒恢复意识。结论：高压氧治疗对持续性植物状态患者有显著疗效。对治疗时间较长超过４０次者，宜分阶段进行，并应注意加强营养供给。

Aim: To assess the efficacy of hyperbaric oxygenation for patients with persistent vege-tative state and to clarify its therapeutic mechanism. Methods:8 patients with persistent vegetative state(PVS)(resulted from head injury 4,cerebral hemorrhage 2, cerebral infarction 1 and after surgery for meningioma 1)were treated with hyperbaric oxygenation(HBO)combined with conventional therapy in the years 1994-1995. The HBO pressure used was 0.2 MPa and the patients breathed pure oxygen for 80 min(with a 10 min break)once a day and 10 times a course. In this set of patients, the times of HBO treatment varied from 20 to 86.Results:All 8 patients resumed consciousness after the HBO combined treatment. Conclusion:HBO has remarkable therapeutic effect on patient with persistent vegetative state. In case of long- term HBO therapy(over 40 times),it should have a break of a reasonable length of time and at the same time good nutrition is needed.