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RTK与结肠肿瘤研究进展

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摘要 RTK即受体酪氨酸激酶,是一类小分子跨膜蛋白质。其结构共同点是均有一个保守的激酶位点。RTK与其配体结合后,使激酶位点磷酸化,激活一系列下游信号途径。在结肠肿瘤中有多种RTK的异常表达,且与肿瘤的恶性程度相关。利用基因治疗或者RTK的抑制剂,可以延缓结肠肿瘤的发展。
作者 蒋萍 李景和
出处 《国际病理科学与临床杂志》 CAS 2005年第4期330-332,共3页 Journal of International Pathology and Clinical Medicine
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