室安卡因与慢心律对室性早搏疗效的对比观察

Comparative Efficacy of Oral ToCainide and Mexiletine ie Patients with Sustainded

对64例持续频发性室性早搏患者，用随机单盲法，分别给口服室安卡因1200mg/日及1800mg/日，慢心律450mg/日及800mg/日，以观察对室性早搏的疗效。结果有效率分别为88％、72％、60％、40％。在两种药物的不同剂量组之间疗效无明显差别（p＞0.05），而在两药之间则差别明显：室安卡因79％、慢心律50％（P＜0.05）。

In a randomized, single-blind study, the efficacy of oral tocainide was oompared with mexiletine in 64 patients with frequent, sustained veutricular premature contrac- tions(VPC). At dosages of 1200mg and 1800mg of tocainide a day. 450mg and 800mg of mexiletine a day, the effective rate of VPC control was88%, 72%, 60% and 40% res - pcetively. There was not Rigmificant differencein efficacy between diffeunt dossges of tocainide or mexiletinf(P>0.05), but there was a Rigmicant differente in efficacy bet- ween tocainide (79‰) and mexiletine (50%), (P<0.05)