摘要
目的:考察不同型号卡波姆对奥沙普秦凝胶体外经皮渗透性的影响,筛选奥沙普秦凝胶的基质。方法:采用Franz扩散池, 以大鼠离体皮肤为屏障,进行体外渗透性实验。结果:以卡波姆940为基质的奥沙普秦凝胶体外渗透系数为22．77／μg／(cm2·h),其 体外渗透性最佳。结论:本文筛选的凝胶基质,可为其生产提供参考依据。
OBJECTIVE： To observe the effects of different types of carbomers on percutaneous permeability of oxaprozin gels in vitro and to opitmize the formulation of oxaprozin gel. METHODS： The permeability test in vitro was carried out by using Franz diffusion cell with rats＇ ex vivo skin as barrier, RESULTS： The ex vivo permeability of oxaprozin gel was the best when the carbomer 940 used as its base material with its ex vivo permeability coefficient at 22.77μg/（cm^2· h） . CONCLUSION：The optimized gel base material can act as bases for the production of oxaprozin gel.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第21期1622-1624,共3页
China Pharmacy
关键词
奥沙普秦
凝胶
渗透系数
透皮吸收
Oxaprozin
Gels
Permeability coefficient
Transdermal absorption
