摘要
目的:考察不同型号卡波姆对奥沙普秦凝胶体外经皮渗透性的影响,筛选奥沙普秦凝胶的基质。方法:采用Franz扩散池, 以大鼠离体皮肤为屏障,进行体外渗透性实验。结果:以卡波姆940为基质的奥沙普秦凝胶体外渗透系数为22.77/μg/(cm2·h),其 体外渗透性最佳。结论:本文筛选的凝胶基质,可为其生产提供参考依据。
OBJECTIVE: To observe the effects of different types of carbomers on percutaneous permeability of oxaprozin gels in vitro and to opitmize the formulation of oxaprozin gel. METHODS: The permeability test in vitro was carried out by using Franz diffusion cell with rats' ex vivo skin as barrier, RESULTS: The ex vivo permeability of oxaprozin gel was the best when the carbomer 940 used as its base material with its ex vivo permeability coefficient at 22.77μg/(cm^2· h) . CONCLUSION:The optimized gel base material can act as bases for the production of oxaprozin gel.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第21期1622-1624,共3页
China Pharmacy
关键词
奥沙普秦
凝胶
渗透系数
透皮吸收
Oxaprozin
Gels
Permeability coefficient
Transdermal absorption