270株鲍曼不动杆菌耐药性分析

Analysis on the Drug Resistance of 270 Strains of Baumanii

目的:了解鲍曼不动杆菌的耐药性,为临床合理选用抗菌药物提供参考。方法:对我院2001年-2004年从临床标本分离 出的270株鲍曼不动杆菌的药敏试验结果进行统计分析。结果:鲍曼不动杆菌检出率为16．6％,对哌拉西林／他唑巴坦无耐药菌株 产生;对亚胺培南和氨苄西林／舒巴坦的耐药率分别为16．3％、22．6％;对阿莫西林／克拉维酸的耐药率为33．3％;对其它抗菌药物 均有较高的耐药率,以头孢菌素类尤甚。结论:加强对鲍曼不动杆菌的耐药性监测,规范抗菌药物的应用,对保持敏感抗菌药物的抗 菌活性具有重要意义。

OBJECTIVE： To study the drug resistance of baumanii so as to provide references for rational use of antibiotics in the clinic. METHODS： The susceptibility test results of 270 strains of baumanii isolated from clinical samples in our hospital during the period of 2001-2004 were analyzed statistically. RESULTS： The isolating rate of baumnii stood at 16.6%, which had no drug resistance strains to piperacillin/tazobactam; its drug resistance rates to lmipenem and ampicillin/sulbactam stood at 16.a% and 22.6%, respectively; its drug resistance rates to amoxicillin/clavulanic acid stood at 33.3%; which had higher drug resistance rates to the other antibacterials, particularly to cephalosporins. CONCLUSIONS： To reinforce the monitoring on the drug resistance of baumanii and to standardize the application of antibacterials are helpful for the maintaining of antibacterial activity of sensitive antibacterials.