急性感染性腹泻临床用药研究

Clinical Medication Study on Acute Infectious Diarrhea

目的:探讨感染性腹泻抗菌药物用药指征,规范用药行为。方法:86例经细菌病原学诊断的急性感染性腹泻患者,除25例 细菌性痢疾有抗菌药物治疗指征外,其余61例普通感染性腹泻患者随机分为病原清除剂(蒙脱石)治疗组33例,抗菌药物对照组 28例,并比较2组疗效。结果:治疗组与对照组总有效率分别为100％、89％(P>0．05),前3d止泻率分别为94％、71％(P<0．05),平均 止泻时间分别为(2±0．79)d、(3．07±1．15)d(P<0．01)。结论:抗菌药物仅适用于霍乱、细菌性痢疾和各种细菌性重症腹泻,蒙脱石治疗 普通感染性腹泻疗效更佳。

OBJECTIVE：To study medication indication of antibacterials for infectious diarrhea so as to standardize medication behavior. METHODS： A total of 86 cases, who were diagnosed etiologically to be acute infective diarrhea infectors were enrolled： of which, only 2S bacillary dysentery cases showed indications for antibacterials therapy, of the other 61 common infectious diarrhea cases, 33 （treatment group） were randomly assigned to receive pathogen scavenger （montmorillonite） and 28 （comrol group） to receive antibacterials. The curative efficacy of the two groups was compared. RESULTS： The total effective rates of the treatment group and the control group were 100% and 89% （P 〉0.05）, respectively, the antidiarrheal rates of which on the first 3 days were 94% and 71%（P〈0.05）, respectively, the average antidiarrheal time were（2± 0.79）days and （3.07 ± 1.15） days（ P 〈 0.01）, respectively. CONCLUSION ： Antibacterials is only effective for the treatment of cholera, bacillary dysentery and various kinds of bacterial severe diarrhea, while montmorillonite is more effective in the treatment of common infectious diarrhea.