药物引起关节疼痛192例文献分析

Drug - induce Arthralgia: Literature Review of 192 Cases

目的:探讨药物引起关节疼痛的一般规律及特点。方法:对1994年1月-2005年6月国内医药学术期刊报道的有关药物 引起关节疼痛192例文献进行统计、分析。结果:关节疼痛可出现在静脉滴注用药过程中,也可在用药几个月后,甚至在长期服药几 年后才出现;引起关节疼痛的药物种类以抗微生物药、循环系统药及消化系统药为主,其中由吡嗪酰胺引起的最多,达110例 (57．29％)。结论:临床应重视药物引起的关节疼痛,以确保用药安全。

OBJECTIVE： To disscuss the general patterns and characteristics of drug-induced arthralgia. METHODS： The literature of 192 cases with drug - induced arthralgia reported in domestic medicinal journals published from Jan. 1994 to Jun. 2005 were analyzed statistically. RESULTS： The onset of arthrositis occurred in the process of intravenous drip infusion, or a few months, even a few years after the medication. The drugs that induced arthrositis were chiefly antimicrobial drugs, circulation system drugs and digestive system drugs, of which, 110 cases （57.29%） involved the use of pyrazinamide. CONCLUSION ： To ensure medication safety, attention should be given to the drug - induced arthralgia for clinical pharmacists.